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Lewis, D.A., Curley, A.A., Glausier, J.R. Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models. Dysregulations of synaptic vesicle trafficking in schizophrenia. Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Dendritic spine alterations in schizophrenia. Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders. Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan. Brain-imaging studies of treatment-resistant schizophrenia: a systematic review. Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice. Genome-scale neurogenetics: methodology and meaning. Large-scale genomics unveils the genetic architecture of psychiatric disorders. Grand challenges in global mental health.
HUMAN BRAIN 3D MODEL CERAMIC UPDATE
The Global Burden of Disease: 2004 Update (WHO Press, 2008).Ĭollins, P.Y. BigBrain enables testing of hypotheses on optimal path lengths between interconnected cortical regions or on spatial organization of genetic patterning, redefining the traditional neuroanatomy maps such as those of Brodmann and von Economo.World Health Organization. "BigBrain" is a free, publicly available tool that provides considerable neuroanatomical insight into the human brain, thereby allowing the extraction of microscopic data for modeling and simulation. We created an ultrahigh-resolution three-dimensional (3D) model of a human brain at nearly cellular resolution of 20 micrometers, based on the reconstruction of 7404 histological sections. Available reference brains, however, are restricted to the macroscopic scale and do not provide information on the functionally important microscopic dimension. BigBrain enables testing of hypotheses on optimal path lengths between interconnected cortical regions or on spatial organization of genetic patterning, redefining the traditional neuroanatomy maps such as those of Brodmann and von Economo.ĪB - Reference brains are indispensable tools in human brain mapping, enabling integration of multimodal data into an anatomically realistic standard space. N2 - Reference brains are indispensable tools in human brain mapping, enabling integration of multimodal data into an anatomically realistic standard space. T2 - An ultrahigh-resolution 3D human brain model